Wip1 Directly Dephosphorylates γ-H2AX and Attenuates the DNA Damage Response
نویسندگان
چکیده
منابع مشابه
The HINT1 tumor suppressor regulates both γ-H2AX and ATM in response to DNA damage
Hint1 is a haploinsufficient tumor suppressor gene and the underlying molecular mechanisms for its tumor suppressor function are unknown. In this study we demonstrate that HINT1 participates in ionizing radiation (IR)-induced DNA damage responses. In response to IR, HINT1 is recruited to IR-induced foci (IRIF) and associates with gamma-H2AX and ATM. HINT1 deficiency does not affect the formatio...
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Comment on: Macurek L, et al. Cell Cycle 2012; 12:251-62.
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Phosphorylation of the histone variant H2AX forms γ-H2AX that marks DNA double-strand break (DSB). Here, we generated the sequencing-based maps of H2AX and γ-H2AX positioning in resting and proliferating cells before and after ionizing irradiation. Genome-wide locations of possible endogenous and exogenous DSBs were identified based on γ-H2AX distribution in dividing cancer cells without irradi...
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(Shen et al., 2000). However, it is not known whether the INO80 complex functions in DNA damage repair Waltham, Massachusetts 02454 directly or indirectly through other mechanisms. Here, we show biochemical and genetic evidence that the INO80 complex is directly involved in DNA repair. The Summary key mechanism is through a specific interaction between the INO80 complex and the DNA damage-While...
متن کاملPhosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage response.
MdmX and Mdm2 regulate p53 tumor suppressor functions by controlling p53 transcriptional activity and/or stability in cells exposed to DNA damage. Accumulating evidence indicates that ATM-mediated phosphorylation and degradation of Mdm2 and MdmX may be the initial driving force that induces p53 activity during the early phase of the DNA damage response. We have recently determined that a novel ...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2010
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-09-4244